PDRN Polydeoxyribonucleotide｜Anti-Inflammatory Repair & Regenerative Raw Material
Technical Specifications
Molecular Weight: 1000–3000 Da
Purity: ≥98%
Endotoxin: ＜0.01 EU/mg
Natural degradation period: 4–8 weeks.
Bioactivity: High-activity nucleic acid fragments, compatible with human nucleic acid metabolism
Product Introduction
Polydeoxyribonucleotide (PDRN) is a medical-grade natural nucleic acid regenerative raw material. Purified from deep-sea salmon reproductive tissues through multi-stage ultrafiltration and impurity removal processes, it eliminates heterologous proteins and sensitizing impurities while retaining highly active natural DNA fragment structures. Widely verified by global clinical practice, PDRN features excellent biocompatibility and high homology with human nucleic acid metabolism with non-immunogenicity, low irritation and complete metabolic safety.
Different from traditional collagen and polysaccharide repair materials, PDRN possesses a unique triple mechanism of anti-inflammation, barrier repair and tissue regeneration. It precisely regulates the tissue inflammatory microenvironment, activates cellular repair potential and promotes soft tissue remodeling. As the core compliant raw material for medical postoperative repair, barrier stabilization and precise anti-aging, it is widely applied in regenerative medicine, soft tissue injury repair and medical biomaterial R&D. It can be compounded with hyaluronic acid, silk fibroin and polypeptides to form composite regenerative systems, supporting the R&D and mass production of high-end medical device materials.
Mechanism of Action
High-purity PDRN nucleic acid fragments exert targeted repair and regeneration effects through dual biological pathways. On the one hand, it activates the human adenosine A2A receptor, effectively inhibits excessive inflammatory responses, eliminates cellular free radicals and reduces oxidative stress, rapidly relieves tissue redness, damage and dry sensitivity. On the other hand, it participates in the human nucleic acid salvage synthesis pathway, providing essential nucleotide precursors for cell proliferation and tissue metabolism. It continuously activates fibroblast activity, induces ordered regeneration of collagen and elastic fibers, and reconstructs a complete dermal fiber network and skin barrier.
PDRN degrades mildly through human natural metabolic pathways without residues, accumulation or irritating metabolites. It achieves progressive effects including immediate anti-inflammatory soothing, medium-term barrier reconstruction and long-term cellular anti-aging, fundamentally improving tissue sensitivity, barrier damage, fine lines, sagging and dullness to realize physiological repair and long-term tissue rejuvenation.
Core Product Advantages
Natural Nucleic Acid Homology with Ultimate Medical Safety
Derived from high-purity deep-sea nucleic acid extracts, its molecular structure matches human nucleic acid metabolism. Non-toxic, non-sensitizing and rejection-free, its degradation products can be directly absorbed and utilized by the human body. It is suitable for postoperative vulnerable tissue, sensitive soft tissue and superficial wound repair with clinically proven high safety.
Exclusive Triple Mechanism of Anti-Inflammation + Repair + Regeneration
Different from conventional moisturizing and filling materials, PDRN owns targeted anti-inflammatory properties to rapidly stabilize inflammation and prevent recurrence. It activates cellular regeneration, repairs barriers, rebuilds dermal matrix and improves aging sagging, solving complex skin and tissue damage problems comprehensively.
Cell-Level Precise Repair & Refined Anti-Aging
Optimizes tissue metabolism and improves cell survival rate at the cellular level. It repairs damaged basal tissue, thickens dermal matrix and improves fine lines, pores, sagging and dullness, restoring delicate, firm and translucent native tissue texture.
Customizable Parameters & Wide Formula Compatibility
Adjustable molecular weight, activity purity, solid content and compounding ratio. It can be used alone or stably compounded with HA, silk fibroin, polypeptides and polyester microspheres, adapting to diversified medical device product lines for postoperative repair, barrier stabilization and anti-aging rejuvenation.
Medical-Grade High-Purity Quality for Device Compliance
Produced by multi-stage ultrafiltration and sterile refining technology with ultra-low impurities, high activity retention and excellent batch consistency. Fully compliant with medical biological raw material standards, all indicators meet the access requirements of medical device repair materials, supporting downstream testing, registration and mass production.
Target Customers & Application Scope
Overseas medical device manufacturers, leading domestic medical aesthetic raw material supply chain groups, biomedical research institutes, biomaterial research laboratories
Commercial Application Scenarios
Mass Production Support for Medical Device Manufacturers
Core raw material for high-purity PDRN anti-inflammatory substrates, PDRN+HA composite regenerative formulas, postoperative repair lyophilized powder and barrier repair gels, supporting R&D and manufacturing of Class II medical devices for postoperative repair and precise anti-aging.
In-Depth Compound Cooperation with Large Raw Material Groups
Supply bulk industrial-grade PDRN raw materials for secondary compounding with bioactive proteins and gel matrices to develop differentiated anti-inflammatory and regenerative composite materials for domestic and overseas distribution.
R&D Sample Cooperation for Scientific Research Institutions
Provide standard samples and customized modified samples for nucleic acid biomaterial research, pre-development of medical repair devices, animal efficacy verification and pre-registration pharmacology and toxicology tests.
Compliance Disclaimer
Our company focuses on the R&D and bulk sales of biomedical raw materials. We do not supply products to medical aesthetic clinics, beauty salons or individual end consumers, nor do we produce, subpackage or sell finished medical aesthetic devices and skincare products. Customers shall independently complete formula development, preparation processing, domestic & overseas medical device registration certification and other commercial procedures. Finished products can only be launched into market after obtaining full compliance approval. The content on this page only objectively demonstrates the physicochemical properties and application directions of raw materials, and shall not be regarded as efficacy commitment for finished medical devices, clinical operation guidance or commercial efficacy endorsement.